Neoro+

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The Natural Fuel for
100% Brain Power.

Improves Focus, Energy, Memory Formation and Recall.
Scientificly Approved by Independent Researches.

*WHY
As human specie starts losing muscle at the age of around 30 years old, the zenith of our integrated brain performance is approximately in our age of 35-45 range. Just like our muscle fibre, our brain neurons degenerate while we ageing, and our brain chemistry and energy metabolism changes, which may lead to:

– Recall, reaction time and mood diminish
– Brain cell membranes degenerate
– Acetylcholine levels decline[1]
– Nerve growth factor in the brain declines
…

All of these age-related changes are contributing factors to the neurodegenerative diseases of aging, including Alzheimer’s and dementia.
As we all know, protein (amino acids) is the essential nutrient for maintaining muscle health besides regular physical exercises, our brain neurons also need consistently supply of certain nutrients to maintain functional while ageing.

*WHAT
Neoro+ is our proudly launched nootropic dietary supplement product for nerve system health. After years of research and clinical tests, our R&D scholars presented this optimized stacking formulation, after piles of convincing evidence of its positive efficacy were collected. All the ingredients are from 100% natural resource, and with science based studies indicating their therapeutic effect.

• Brain Power Booster
• Concentration
• Memory Optimization
• Anxiety Relief
• Anti Brain Fatigue
• Neuro Protection & Regenesis

-Ingredients:
Alpha GPC (99%)
Phosphatidylserine (60%)
Radix Polygalae 20:1 Extract
Bacopa Monnieri (71% bacosides)

WHAT IS alpha-GPC?

Alpha-GPC (L-Alpha glycerylphosphorylcholine) is a natural choline compound found in our body. It could be produced in small amounts by ourselves, but the quantity of the auto-synthesized choline is comparatively quite insufficient so we need to have supplemental choline, either from food or a supplement.
The brain contains a number of cholinergic areas, each with distinct functions, which playing an important role in arousal, attention, memory and motivation[2]. Choline is considered an essential nutrient which is so vital to cognition and nerve function that, without it, we couldn’t move, think, sleep or remember anything. We need choline as a biosynthetic precursor of the neurotransmitter acetylcholine, which plays a critical role in the neocortex[3]. Also to form phosphatidylcholine (PC) used in building brain cell membranes.
Alpha-GPC could rapidly delivers choline to the brain across the blood–brain barrier (BBB) comparing to other sources of choline, such like CDP-choline or Choline Bitartrate.
Alpha GPC boosts brain health and function in several ways.
Acetylcholine functions both as a neurotransmitter and a neuromodulator, tied to memory formation, learning capacity, attention and overall brain function. Alpha GPC, a biosynthetic precursor of acetylcholine, acts as a neuropretectant by facilitating the production of acetylcholine therefore increasing the neural signaling and improving the communication efficiency between neurons in your brain. In one study, the researchers found Alpha GPC was able to prevent the impairment of attention and memory normally caused by scopolamine. These researchers showed that memory function in young healthy people could be racked up a notch, simply by taking Alpha GPC as a supplement[4].
Alpha GPC directly impacts development of cell membranes in the cerebral cortex. This outer layer of neural tissues or “gray matter” is the information processing center of your brain. It controls intelligence, motor function, organization, personality, planning and touch[5]. Published in Clinical Therapeutics, researchers conducted a double-blind, placebo-controlled trial with mild to moderate Alzheimer’s patients. 400 mg capsules were administered 3- times per day for 180 days. The conclusion of this trial showed consistent improvement in dementia patients given Alpha GPC[6].
Alpha GPC has been investigated for its potential for the treatment of Alzheimer’s disease and other dementias, from the aspect of neural science. Furthermore, it is actually used throughout our body. It even helps the production of human growth hormone. Athletes use it for peak performance, and to help build lean muscle mass. It provides more energy for a workout and quicker recovery[7].

– Benefits and Effects
* Improves Memory Formation and Recall[8][9][10]
* Neuroprotection and Development of New Brain Cells[11]
* Increases Energy and Speeds up Recovery[12][13][14]
* Increases Attention and Enhances Mood[15]
* Boosts memory and attention[15]
* Promotes recovery in stroke patients[16]
* Reverses the symptoms of acute cerebrovascular disease[16]
* Is far more effective than using choline or lecithin in treating disease

Alpha GPC

 

 

 

Acetylcholine

By NEUROtiker – Own work, Public Domain, https://commons.wikimedia.org/w/index.php?curid=2125698

WHAT IS PHOSPHATIDYLSERINE?

Phosphatidylserine (PS) is the major acidic phospholipid class that accounts for 13–15% of the phospholipids in the human cerebral cortex[17]. As an amino acid derivative compound, it is a phospholipid component of the cell membrane encasing every one of our brain cells. It is a natural substance that helps cells membrane stay pliable and is thought to boost the effectiveness of neurotransmitters, which relay brain signals[18]. It is also involved in building mitochondria which are the energy centers of each brain cell, and helps maintain the fluidity and permeability of brain cells. Allowing for the efficient transfer of proteins, enzymes, nutrients, oxygen and glucose into and out of each cell[19].

Phosphatidylserine is essential for cellular health, structure, and protection, but that’s just part of the PS picture: studies show that also a powerful nootropic that may sharpen memory, increase focus, and enhance the ability to learn, reason, and solve problems‍[20], and it’s vital to virtually all aspects of cognitive function, including memory, mental processing speed and accuracy, and language. It has also been shown to fight the effects of stress and is believed to prevent or delay the onset of age-related cognitive decline effectively‍[21]. Studies show that PS levels decline with age[22]‍,‍ suggesting that natural production and dietary assimilation may become less efficient as we get older. This change means that supplementation may be key to realizing the many therapeutic and nootropic benefits PS offers. For elderly, one of the main benefits of phosphatidylserine is preventing cognitive decline. One Japanese study of elderly individuals showed that taking phosphatidylserine for 6 months could stave off cognitive decline and signs of dementia[23]‍. Another study of Alzheimer’s patients suggested three weeks of supplementation could reduce symptoms of cognitive decline[24]‍. While some evidence confounds these results, the common trend suggests that middle-age and elderly people can prevent many symptoms of cognitive decline with phosphatidylserine.

On the other end of the spectrum, PS is well studied for children who are struggling with ADHD, two months of supplementation of 200mg PS appears to improve symptoms of global and subscale attention deficit and hyperactivity disorders in children with ADHD, and secondary to improving symptoms of ADHD an improvement in short-term auditory memory and impulsivity was noted[25]‍. [Other studies in children with ADHD have noted promise when pairing PS with fish oil supplementation, with some using a phosphatidylserine structure with the fish oil fatty acids (EPA and DHA) attached to the glycerol backbone[26](study duplicated in Medline[27]) and appears to enhance erythrocytic fish oil fatty acid levels to a level greater than fish oil itself[28].]

Phosphatidylserine works in conjunction with DHA (omega-3) in cells and keeps brain cells optimized for the neurotransmitters dopamine, serotonin, and norepinephrine in the brain[29]‍. PS promotes healthy nerve growth factor (NGF) and supports the neurogenesis required for long-term potentiation (LTP). Memory formation depends on healthy LTP, and PS increases the number of neurons in a brain cell and promotes the development of new neurons by supporting healthy nerves and the growth of nerve growth factors (NGF)[30]‍.

– Benefits and Effects
* Improves Memory
* Reduces the Negative Effects of Stress
* Improves Symptoms of Depression
* Relieves Symptoms of Alzheimer’s and Parkinson’s Diseases
* May Delay the Onset of Age-Related Cognitive Decline
* Boosts Endurance and Improves Athletic Performance {https://www.braintropic.com/nootropics/phosphatidylserine/}

(Phosphatidylserine is a phospholipid—more specifically a glycerophospholipid—which consists of two fatty acids attached in ester linkage to the first and second carbon of glycerol and serine attached through a phosphodiester linkage to the third carbon of the glycerol[31]. Phosphatidylserine sourced from plants differs in fatty acid composition from that sourced from animals[32]. That’s why our PS is sourced from animal brain tissue.)

WHAT IS RADIX POLYGALAE?

Radix Polygalae, in Chinese it’s called “Yuan Zhi” (Chinese: 遠志).
While our researchers screening for NOO?, we found this intriguing plant.

(Traditional Chinese medicine: a promising candidate for the treatment of Alzheimer’s disease (nih.gov))

Currently, learning and memory ability has been regarded as one of the most important functions in our daily lives, with increasing of life span[33][34]. The elderly always feel that cognitive ability get worse and worse during daily activities. As the aging people grow rapidly, the number of patients suffering from progressive neurodegenerative diseases (ND) including Alzheimer’s and Parkinson’s diseases is gradually increased in the worldwide[35][36]. The cognitive impairments are the most common and critical symptom shown in the diseases[37][38]. ND patients are expected to be an economic and social burden in the near future because they require medical treatment and care giving for a very long time[39][40][41].

Moreover, young generation such as adolescent and students requires better cognitive function because they have to learn and memorize a lot of information and knowledge[42]. Various natural products containing biologically active components have been used as a functional food in the world. Recently, cumulative attention has been devoted to not only the prevention and treatment of disease but also maintaining and strengthening health by natural products or herbal medicines. Beneficial effects of functional food may help improve the health healthy condition and reduce the risk of disease onset during early stage growth process and older ages[43]. Therefore, it needs to develop functional food or medication that can help learning and memory abilities in young people as well as prevent the progressive cognitive deficits in aging people and ND patients.

Roots of Polygala tenuifolia has been traditionally used because of beneficial effects such as: sleeping time enhancement, anti-depression, neuroprotection, anti-inflammatory, MAO-B inhibition, anti-seizure and anti-stress in humans[44][45][46][47]. In animal and human studies, the root extract of Polygala tenuifolia (BT-11) improved cognitive function significantly[48][49][50]. BT-11 also showed anticholinesterase, neuroprotective and antioxidative efficacies in toxin-induced disease models of animal and cell[51][52].
Generally, memory as measured by changes in an animal’s behavior some time after learning is considered to be a process that has several stages, including acquisition, consolidation and retrieval[53]. The improvement of learning and memory of aged mice is mediated by the effects of tenuifolin on the three stages of memory process, that is, acquisition, consolidation and retrieval. This may do so by relatively increasing the levels of NE, DA in the hippocampus and by decreasing the activity of AChE in the cortex[48].

– Benefits and Effects
* Enhances memory
* (May treat) Alzheimer’s & Parkinson’s Disease
* Relieves anxiety & depression
* Anti-inflammatory
* Improves sleep quality
* Anti-tumor effects

WHAT IS BACOPA MONNIERI?

Bacopa Monnieri has been used for medicinal purposes in Ayurvedic medicine in India for more than 3000 years. It was thought to be so beneficial to the mind and had been a staple of Ayurvedic medicine as a powerful tool to enhance cognitive abilities, reduce anxiety and even protect the brain against aging.
Bacopa monnieri (also known as Brahmi, water hyssop, and Herpestis monniera) is a creeping perennial plant that has been shown to have anticonvulsant, antidepressant, analgesic, anti-inflammatory, anxiolytic, adaptogenic, and neuroprotective effects[54][55][56]. Bacopa monnieri also has an important role in cellular homeostasis by modulating apoptosis through autophagy[57][58][59]. As a functional food, Bacopa monnieri is often referred to as a nootropic agent that improves memory and mental acuity[56]. In India, it has been used as a component in drinks, biscuits, syrups, jellies, and breakfast cereals[60]. The main bioactive constituents of Bacopa monnieri believed to be associated with its cognitive effects are saponins called bacosides, with bacosides A and B the most studied constituents[56]. Specifically relating to the pathophysiological processes associated with sleep disturbances, Bacopa monnieri has been shown to influence HPA-axis activity[61][62], neurotransmitter concentrations of dopamine and serotonin[63[64], and antioxidant and inflammatory activity[65][66]. In experimental studies, bacoside A inhibited inflammatory cytokine production[67], reduced free radical damage in the liver and brain[68], inhibited inflammatory cytokine production in the brain[66], and inhibited beta-amyloid cytotoxicity[69]. Due to the association between inflammation, oxidative stress, HPA-axis activity, and neurotransmitter concentrations, Bacopa monnieri has promise as a sleep-promoting and mood-enhancing agent. In human trials, Bacopa monnieri has been shown to have positive cognitive[70][71][72][73] and anxiolytic[73][74] effects.

– Benefits and Effects
* Memory enhancement[75][76]
* Anti-anxiety[77]
* Attention and focus enhancement[76][78]

*WHOM

Students

Business Elites

Athletes

Active 65+

Dosage and Side effects:
Since Acytlecholine and Nicotine share the same receptors, so if you smoke, take 3 capsules each time.

References:

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  2. Kapalka, George M. (2010). “Substances Involved in Neurotransmission”. Nutritional and Herbal Therapies for Children and Adolescents. Elsevier. pp. 71–99. doi:10.1016/b978-0-12-374927-7.00004-2. ISBN 978-0-12-374927-7.
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      For a hopeful future.

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